Monoclonal antibody to human LBP - biG 48
Description
Category |
Mouse monoclonal antibody - Protein G purified - lyophilized |
Reconstitution |
For reconstitution add 50 µl distilled water. |
Isotype |
IgG1 |
Antigen |
LBP knock out mouse immunized with immunoaffinity purified recombinant human LBP,a 58KD glycoprotein. |
Special note |
It is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (LPS) to elicit immune responses by presenting the LPS to CD14 and TLR4. |
Characteristic |
No inhibition of LPS binding to membrane bound CD14; Binding site is not directly involved in LBP-LPS-CD14 interaction. |
Application |
ELISA, LBP inhibition studies, Western Blot |
Storage |
Long time storage at -20°C or -80°C |
Quantity |
100 µg in PBS without NaN3 or other stabilisation before lyophilisation |
IgG-content | 2 mg/ml (determined by mouse IgG-ELISA) |
References
Okawa,T. Asai,Y. Hashimoto, M. Uchida,H. Bacterial fimbriae activate human peripheral blood monocytes utillizing TLR2,CD14 and CD11a/CD18 and cellular receptors Eur. J. Immunology 2002,32(9): 2543-2550
Roes, Stefanie Florian Mumm, Ulrich Seydel, and Thomas Gutsmann Localization of the Lipopolysaccharide-binding Protein in Phospholipid Membranes by Atomic Force Microscopy*1 J. Biol. Chem., Vol. 281, Issue 5, 2757-2763, February 3, 2006
