Monoclonal antibody to human LBP - biG 42
Description
Category |
Mouse monoclonal antibody - Protein G purified - lyophilized |
Reconstitution |
For reconstitution add 100 µl distilled water. |
Isotype |
IgG1 |
Antigen |
LBP knock out mouse immunized with immunoaffinity purified recombinant human LBP,a 58KD glycoprotein. |
Special note |
It is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (LPS) to elicit immune responses by presenting the LPS to CD14 and TLR4. |
Characteristic |
Without inhibition of LPS binding to membrane bound CD14, binding titre at human LBP- ELISA: 1:10.000. |
Application |
ELISA, LBP inhibition studies, Western Blot, immune histochemistry |
Storage |
Long time storage at -20°C or -80°C |
Quantity |
100 µg in PBS without NaN3 or other stabilisation before lyophilisation |
IgG-content | 1 mg/ml PBS |
References
Rahmana ,Md. Mizanur,c, et al. Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues , Veterinary Immunology and Immunopathology 2010
Andrä, J., Koch, M.H.J., Barels, R., Brander, K.: Biophysical Characterization of Endotoxin inactivation by antimicrobial peptide derived from Mammalian, NK-Lysi, Antimicrobial agents Chemother. 2004, 48/5: 1593-1599
Ren, L. et al The expression profile of LBP, membrane bound CD14, and Toll like receptors 2 and 4 in chronic periodontitis Journal of Periodontal ResearchVol.76/11 1950, 2005
Ren,Lei , Lijian Jin, W. Keung Leung Local expression of lipopolysaccharide-binding protein in human gingival tissues Journal of Periodontal Research Vol. 39 Issue 4 Page 242 August 2004
M. Mueller, B. Lindner, R. Dedrick, A.B. Schromm and U. Seydel, Endotoxin: physical requirements for cell activation Journal of Endotoxin Research 2005; 11; 299
