Monoclonal antibody to human LBP - biG 42



Mouse monoclonal antibody - Protein G purified - lyophilized


For reconstitution add 100 µl distilled water.




LBP knock out mouse immunized with immunoaffinity purified recombinant human LBP,a 58KD glycoprotein.

Special note

It is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (LPS) to elicit immune responses by presenting the LPS to CD14 and TLR4.


Without inhibition of LPS binding to membrane bound CD14, binding titre at human LBP- ELISA: 1:10.000.
Binding site is not directly involved in LBP-LPS-CD14 interaction.


ELISA, LBP inhibition studies, Western Blot, immune histochemistry


Long time storage at -20°C or -80°C


100 µg in PBS without NaN3 or other stabilisation before lyophilisation

IgG-content 1 mg/ml PBS




Rahmana ,Md. Mizanur,c, et al. Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues , Veterinary Immunology and Immunopathology 2010


Andrä, J., Koch, M.H.J., Barels, R., Brander, K.: Biophysical Characterization of Endotoxin inactivation by antimicrobial peptide derived from Mammalian, NK-Lysi, Antimicrobial agents Chemother. 2004, 48/5: 1593-1599


Ren, L. et al The expression profile of LBP, membrane bound CD14, and Toll like receptors 2 and 4 in chronic periodontitis Journal of Periodontal ResearchVol.76/11 1950, 2005



Ren,Lei , Lijian Jin, W. Keung Leung Local expression of lipopolysaccharide-binding protein in human gingival tissues Journal of Periodontal Research Vol. 39 Issue 4 Page 242 August 2004


M. Mueller, B. Lindner, R. Dedrick, A.B. Schromm and U. Seydel, Endotoxin: physical requirements for cell activation Journal of Endotoxin Research 2005; 11; 299


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