Monoclonal antibodies (mab) to human CD14
cat. no |
mab |
isotype |
CD14 epitope |
characteristics |
biG 10 |
IgG1 |
amino acid (aa) 9-13, |
inhibits LPS-binding to CD14 |
|
biG 13 |
IgG1 |
aa 9-13, aa 39-44 |
inhibits LPS-binding to CD14 |
|
biG 14 |
IgG2a |
aa 39-44 |
inhibits LPS-binding to CD14 |
|
biG 2 |
IgG2a |
aa 147-152 |
no inhibition of LPS-binding to CD14 |
|
biG 4 |
IgG1 |
aa 33-44 |
no inhibition of LPS-binding to CD14 |
|
biG 7 |
IgG1 |
beyond N-terminal |
no inhibition of LPS-binding to CD14 |
Antibody preparation
cat. no |
antibody preparation |
size |
c |
protein G purified IgG |
0.1 mg |
References
Stelter, F. et al. (1996): The myeloid differentiation antigen CD14 is N- and O-glycosylated. Contribution of N-linked glycosylation to different soluble CD14 isoforms. Eur. J. Biochem. 236, 457-464
F. Stelter et al. Eur. J. Biochem 243, 100-109, 1997
Dziarski.R. Tapping,R.I. Tobias P.S. et al Binding of bacterial Peptidoglycan to CD14, J. Biol Chem.1998,273(15) 8680-8690
Vanlandschoot, P. Van Houtte,F. Roobrouck,A. Farhoudi,A. et al. LPS-binding protein an CD14-dependent attachment of hepatitis B Surface antigen to monocytes is determined by the phospholipid moity of the particles. J of General Virology 2002, 83:2279-2289
Vanlandshoot, P., F. van Houtte, P. Ulrichs, J. Tavemier, G. Leroux-Roel Immunostimulatory potential of hepatitis B nucleocapsid preparations:Lipopolysaccharide contamination should not be overlooked J. of General Virology 2005, 86:323.331
Lührmann,A. Thölke J. Schumann,J. et al Immunomodulating Properties of the antibiotic Novobiocin in Human Monocytes, Antimicrobial Agents and Chemo-therapy 1998,42(8):1911-1916
